Anabolic Role of Human Growth Hormone

Human Growth Hormone - Playing an Anabolic Role in the Body

The Somatotroph cells (hence called Somatotropin) present in the anterior pituitary gland synthesizes and secretes human growth hormone which is a protein hormone consist of 190 amino acids. In the q22-24 region of chromosome 17, the genes for human growth hormone are localized. Four helices necessary for functional interaction with the GH receptor is included in the structure of human growth hormone. Structurally, human growth hormone is homologous to prolactin and chorionic somatomammotropin and it looks like the three share some evolutionarily connection. For promoting growth and aiding the lactogenic activity, this triad is known.

Secretion of human growth hormone

Many factors including exercise, nutrition, sleep, stress controls the synthesis and secretion of human growth hormone and sometimes even growth hormone contribute itself. However, two hypo-thalamic hormones (Growth hormone-releasing hormone or GHRH and Somatostatin or SS) and one hormone present in the stomach (Ghrelin) wield the control.

Human growth hormone functions

Human growth hormones have contribution in the building up of the human body. Human growth hormone has two different types of effects direct and indirect on the human tissues and the human system as a whole. The upshot of the growth hormone binding its receptor to the target cells are the direct effect while an insulin-like growth factor-I (IGF-I) hormone secreted by the liver and other tissues in response to growth hormone action stimulates the indirect effect. In fact, IGF-I acting on the target cells causes the most of the growth promoting effects of human growth hormone. Thus, a vital role is played in major physiological processes, including growth and metabolism by human growth hormone or Somatotropin.

Effect of human growth hormone on growth

Growth of body is affected by growth hormone which plays a major role by stimulating the liver and various other tissues to secrete IGF-I. IGF-I. Which in-turn provokes proliferation of Chondrocytes (cartilage cells), that results in bone growth.

Metabolism & human growth hormone

Important effects of human growth hormone have been found on protein, lipid and carbohydrate metabolism. Some of the effects are direct, others indirect while few show mixed effects.

Human growth hormone has several other specific and essentially functions including most important effect height growth on the human system. These functions include protein synthesis, building muscle mass, calcium retention, mineralization of bones, stimulating the immune system, maintaining fuel homeostasis etc.

Until now, we are talking all about real human growth hormone. In 1985, for the remedial use, Biosynthetic human growth hormone was first used which is known as recombinant human growth hormone and abbreviated as human growth hormone After that, pituitary-prompted human growth hormone, especially in therapeutic use has been almost sidelined by the biosynthetic variety of human growth hormone.

What is Human Growth Hormone
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